Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights.

ABSTRACT: Aim: To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.Materials & methods: Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using in vitro assays and molecular docking studies.Results: The complexes exhibited significant antimalarial activity against Plasmodium falciparum, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.

SUBMITTER: Bhardwaj A 

PROVIDER: S-EPMC11622762 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature