<i>In silico</i> studies, synthesis, characterization and <i>in vitro</i> studies of levosulpiride derivatives.

ABSTRACT: Aim: Breast cancer is the most recurring cancer among females and is being diagnosed as a major cause of death among women.Materials & methods: Levosulpiride Schiff base derivatives were synthesized and analyzed by physical and spectral (FTIR, ¹H-NMR, ¹³C-NMR) analysis. MTT assay against MCF-7 (human breast cancer cell line), scavenging activity and Molecular docking against receptors 1M17, 3PP0, 3IOK and 4KIK along ADME pharmacokinetic studies were performed.Results & conclusion: L1 and L3 synthesized derivatives have revealed better percent cell viability and inhibitory concentration (IC₅₀) with scavenging activity as of the parent compound. L1, L3 and L9 revealed significant docking scores compared with standard drugs. Most of the de

SUBMITTER: Akram MT 

PROVIDER: S-EPMC11622800 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature