Circular RNAs as multifaceted molecular regulators of vital activity and potential biomarkers of aging.

ABSTRACT: Aging presents a significant challenge to health and social care systems due to the increasing proportion of the elderly population. The identification of reliable biomarkers to assess the progression of aging remains an unresolved question. Circular RNAs (circRNAs) are single-stranded covalently closed RNAs. They have been found to regulate various biological processes. CircRNAs are present in human biological fluids, are relatively stable, and accumulate with age, making them promising as biomarkers of aging. Current information on the expression of circRNAs in aging was analyzed using scientific databases. In this review, we have identified key stages in the study of circRNAs during aging and summarized the current understanding of their biogenesis. By focusing on the role of circRNAs i

SUBMITTER: Zharova AD 

PROVIDER: S-EPMC11622801 | biostudies-literature | 2024 Dec-Dec

REPOSITORIES: biostudies-literature