TRNA-derived RNAs in human milk extracellular vesicles and associations with breastfeeding variables and maternal diet.

ABSTRACT:

Aims

To describe tDRs in human milk EVs and their associations with maternal body mass index, age, dietary indices, breastfeeding frequency, season and time of milk collection in a Latina population.

Materials & methods

We sequenced small RNAs from EVs from 109 mature human milk samples collected at 1 month after delivery in the Southern California Mother's Milk Study. We grouped tDRs using hierarchical clustering and clusters were compared across tDR characteristics. We analyzed associations of tDRs with intrinsic maternal variables (body mass index, age), maternal nutrition (caloric intake, Healthy Eating Index, Dietary Inflammatory Index), and variables related to feeding and milk collection (breastfeeding frequency, season and time of milk collection) using negative bino

SUBMITTER: Gaylord A 

PROVIDER: S-EPMC11622811 | biostudies-literature | 2024 Dec-Dec

REPOSITORIES: biostudies-literature