Dietary fats and the APOE-e4 risk allele in relation to cognitive decline: a longitudinal investigation in a biracial population sample.

ABSTRACT:

Background

APOE-e4 is the strongest genetic risk factor for Alzheimer's disease. However, the influence of APOE-e4 on dietary fat intake and cognition has not been investigated.

Objective

We aim to examine the association of types of dietary fat and their association to cognitive decline among those with and without the APOE-e4 allele.

Methods

The study included 3,360 Chicago Health and Aging Project (CHAP) participants from four Southside Chicago communities. Global cognition was assessed using a composite score of episodic memory, perceptual speed, MMSE, and diet using a 144-item food frequency questionnaire. APOE genotype was assessed by the hME Sequenom mass-array platform. Longitudinal mixed-effect regression models were used to examine the association of dietary

SUBMITTER: Liu X 

PROVIDER: S-EPMC11623058 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature