Association of vitamin D receptor gene polymorphisms with rheumatoid arthritis.

ABSTRACT:

Introduction

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology which causes progressive deterioration of the joints, leading to severe pain and functional disability. Vitamin D and its receptor (VDR) play a significant part in the onset of autoimmune diseases such as RA. The purpose of this study was to evaluate the association between VDR gene polymorphisms and risk of developing RA.

Material and methods

A retrospective study was performed, including 214 RA cases and 748 controls of Caucasian origin. FokI (rs2228570), BsmI (rs1544410), TaqI (rs731236), ApaI (rs7975232) and Cdx2 (rs11568820) gene polymorphisms were analyzed by TaqMan.

Results

The recessive logistic regression model show

SUBMITTER: Marquez Pete N 

PROVIDER: S-EPMC11623149 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature