Charting the transcriptomic landscape of primary and metastatic cancers in relation to their origin and target normal tissues.

ABSTRACT: Metastasis is a leading cause of cancer-related deaths, yet understanding how metastatic tumors adapt from their origin to their target tissues remains a fundamental challenge. To address this, we assessed whether primary and metastatic tumors more closely resemble their tissues of origin or target tissues in terms of gene expression. We analyzed expression profiles from multiple cancer types and normal tissues, including single-cell and bulk RNA sequencing data from both paired and unpaired patient cohorts. Primary tumors were overall more transcriptomically similar to their tissues of origin, while metastases shifted toward their target tissues. However, pathway-level analysis highlighted critical metabolic and immune transcriptomic changes toward target tissues during metastasis in both

SUBMITTER: Sanghvi N 

PROVIDER: S-EPMC11623296 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature