Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function.

ABSTRACT:

Background

Protein quality control (PQC) is critical for maintaining sarcomere structure and function in cardiac myocytes, and mutations in PQC pathway proteins, such as CRYAB (arginine to glycine at position 120, R120G) and BAG3 (proline to lysine at position 209, P209L) induce protein aggregate pathology with cardiomyopathy in humans. Novel observations in yeast and mammalian cells demonstrate mitochondrial uptake of cytosolic protein aggregates. We hypothesized that mitochondrial uptake of cytosolic protein aggregates and their removal by mitophagy, a lysosomal degradative pathway essential for myocardial homeostasis, facilitates cytosolic protein quality control in cardiac myocytes.

Methods

Mice with inducible cardiac myocyte specific ablation of TRAF2 (TRAF2icKO), which

SUBMITTER: Rawnsley DR 

PROVIDER: S-EPMC11623534 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature