Delivery of Peptide Coacervates to Form Stable Interaction Hubs in Cells.

ABSTRACT: Cells contain membrane-bound and membraneless organelles that operate as spatially distinct biochemical niches. However, these subcellular reaction centers lose fidelity with aging and as a result of disease. A grand challenge for biomedicine is restoring or augmenting cellular functionalities. Although commonly tackled by gene replacement therapy, an excited new strategy is the delivery of protein-based materials that can directly interact with and alter biological networks inside a cell. In this study we sought to develop long-lasting materials capable of cellular uptake and incorporation, akin to an artificial organelle or intracellular interaction hub. Drawing inspiration from protein-based membranelles organelles, we developed a new delivery method to transplant micron size peptide-ba

SUBMITTER: Tu W 

PROVIDER: S-EPMC11623604 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature