Convergent molecular signatures across eating disorders and obsessive-compulsive disorder in the human brain.

ABSTRACT: Eating disorders (ED) and obsessive-compulsive disorder (OCD) exhibit significant clinical and genetic overlap, yet their shared molecular mechanisms remain unclear. We conducted a transcriptomic investigation of the dorsolateral prefrontal cortex (DLPFC) and caudate from 86 controls, 57 ED, and 27 OCD cases. ED was associated with robust differentially expressed genes (DEGs): 102 DEGs the DLPFC and 222 in the caudate (FDR < 1%) and replicated in an independent cohort. For OCD, no DEGs reached significance; however, meta-analysis with extant data identified 57 DEGs in the caudate. High concordance in transcriptomic changes was observed between ED and OCD in both regions (DLPFC r=0.67, caudate r=0.75). A combined ED+OCD analysis uncovered 233 DEGs in the DLPFC and 816 in the c

SUBMITTER: Breen MS 

PROVIDER: S-EPMC11623724 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature