Influence of Genetic Ancestry on Gene-Environment Interactions of Polygenic Risk and Sociocultural Factors: Results from the Hispanic Community Health Study/Study of Latinos.

ABSTRACT:

Background

Many present analyses of Hispanic/Latino populations in epidemiologic research aggregate all members of this ethnic group, despite immense diversity in genetic backgrounds, environment, and culture between and across Hispanic/Latino background groups. Using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we examined the role of self-identified background group and genetic ancestry proportions in gene-environment interactions influencing the relationship between body mass index (BMI) and a polygenic score for BMI (PGS_BMI).

Methods

Weighted univariate and multivariable generalized linear models were executed to compare the effects of environmental variables identified a priori by McArdle et al. 2021. Both Amerindigenous (AME) ances

SUBMITTER: Sharma J 

PROVIDER: S-EPMC11623730 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature