Advancing Gene Discovery for Substance Use Disorders Using Additional Traits Related to Behavioral Disinhibition.

ABSTRACT:

Importance

Substance use disorders (SUDs) frequently co-occur with each other and with other traits related to behavioral disinhibition, a spectrum of outcomes referred to as externalizing. Nevertheless, genome-wide association studies (GWAS) typically study individual SUDs separately. This single-disorder approach ignores genetic covariance between SUDs and other traits and may contribute to the relatively limited genetic discoveries to date.

Objective

To identify the most effective model for capturing genetic relationships between SUDs and externalizing phenotypes, optimizing the detection of genetic influences on SUDs while maintaining specificity.

Design

We used Genomic SEM to estimate SNP effects on a broad factor representing liability to externalizing and SUDs,

SUBMITTER: Poore HE 

PROVIDER: S-EPMC11623735 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature