Multi-ancestry genome-wide association study reveals novel genetic signals for lung function decline.

ABSTRACT:

Rationale

Accelerated decline in lung function contributes to the development of chronic respiratory disease. Despite evidence for a genetic component, few genetic associations with lung function decline have been identified.

Objectives

To evaluate genome-wide associations and putative downstream functionality of genetic variants with lung function decline in diverse general population cohorts.

Methods

We conducted genome-wide association study (GWAS) analyses of decline in the forced expiratory volume in the first second (FEV₁), forced vital capacity (FVC), and their ratio (FEV₁/FVC) in participants across six cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. Genotypes were impute

SUBMITTER: Patchen BK 

PROVIDER: S-EPMC11623738 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature