A 2-year longitudinal investigation of insula subregional volumes in early psychosis.

ABSTRACT:

Background

The insula is a heterogeneous cortical region with three cytoarchitectural subregions-agranular, dysgranular, and granular-that have distinct functional roles. Previous cross-sectional studies have shown smaller volume of all insula subregions in individuals with psychotic disorders. However, longitudinal trajectories of insula subregions in early psychosis, and the relationship between subregional volumes and relevant clinical phenomena, such as perceptual aberrations, have not been previously examined.

Methods

66 early psychosis (EP) and 65 healthy comparison (HC) participants completed 2-4 study visits over 2 years. T1-weighted structural brain images were processed using longitudinal voxel-based morphometry in CAT12 and segmented into anatomic subregions. At b

SUBMITTER: Kittleson AR 

PROVIDER: S-EPMC11623745 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature