Anti-neuroinflammatory and neuroprotective potential of Cissus tuberosa ethanol extract in Parkinson's disease model through the modulation of neuroinflammatory markers.

ABSTRACT: The plant Cissus tuberosa Moc is abundant in phenolics, has been documented to have neuroprotective properties. The study seeks to determine the neuroprotective effects of C. tuberosa ethanolic extract (CTE) against Parkinson's disease by evaluating its impact on motor dysfunction, cognitive deficits, neuroinflammation, and neurodegeneration in paraquat-induced Parkinson's disease models. The research hypothesizes that CTE can modulate key biomarkers involved in Parkinson's pathology, including α-synuclein, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), assessed through qRT-PCR, as well as interleukin-6 (IL-6) and TNF-α, evaluated through ELISA. Parkinson disease was induced by using paraquat intraperitoneally. The study was designed by considering various groups with their r

SUBMITTER: Saadullah M 

PROVIDER: S-EPMC11623804 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature