Tissue-resident memory T cells contribute to protection against heterologous SARS-CoV-2 challenge.

ABSTRACT: New vaccine formulations are based on circulating strains of virus, which have tended to evolve to more readily transmit human to human and to evade the neutralizing antibody response. An assumption of this approach is that ancestral strains of virus will not recur. Recurrence of these strains could be a problem for individuals not previously exposed to ancestral spike protein. Here, we addressed this by infecting mice with recent SARS-CoV-2 variants and then challenging them with a highly pathogenic mouse-adapted virus closely related to the ancestral Wuhan-1 strain (SARS2-N501YMA30). We found that challenged mice were protected from severe disease, despite having low or no neutralizing antibodies against SARS2-N501YMA30. T cell depletion from previously infected mice did not diminish inf

SUBMITTER: Odle A 

PROVIDER: S-EPMC11623939 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature