Dysregulation of septin cytoskeletal organization in the trabecular meshwork contributes to ocular hypertension.

ABSTRACT: Ocular hypertension, believed to result partly from increased contractile activity, cell adhesive interactions, and stiffness within the trabecular meshwork (TM), is a major risk factor for glaucoma, a leading cause of blindness. However, the identity of molecular mechanisms governing organization of actomyosin and cell adhesive interactions in the TM remains limited. Based on our previous findings, in which proteomics analyses revealed elevated levels of septins, including septin-9 in human TM cells treated with the ocular hypertensive agent dexamethasone, here, we evaluated the effects of septin-9 overexpression, deficiency, and pharmacological targeting in TM cells. These studies demonstrated a profound impact on actomyosin organization, cell adhesion, contraction, and phagocytosis. Ove

SUBMITTER: Maddala R 

PROVIDER: S-EPMC11623952 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature