Changes in Response Inhibition, Visual Anticipation and Verbal Fluency During Vagus Nerve Stimulation Therapy in Patients With Drug-Resistant Epilepsy.

ABSTRACT:

Background

The effect of vagus nerve stimulation (VNS) on cognitive domain of attention and executive functions (AEFs) has not been extensively researched. This study was set up to investigate performance variability on cognitive tests assessing AEFs in drug-resistant epilepsy (DRE) patients receiving VNS therapy during a follow-up of up to 5 years.

Methods

Thirty-three DRE patients were assessed with the interference, maze, and written verbal fluency tests as a part of EpiTrack screening before and after VNS implantation through repeated follow-ups according to the clinical VNS protocol. A linear mixed-effects model was used to analyse changes in test scores.

Results

Maze performance improved significantly by an average of 0.20 s per month (95% confidence interval (C

SUBMITTER: Lahde N 

PROVIDER: S-EPMC11624008 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature