Prenatal and early life exposure to fine particulate matter and telomere length in early childhood.

ABSTRACT:

Background

Telomere length is a biomarker of molecular aging that may be impacted by air pollution exposure starting in utero. We aimed to examine the association between prenatal and early life exposure to fine particulate matter (PM_2.5) and leukocyte telomere length (LTL) in children and explore sex differences.

Methods

Analyses included 384 mother-child pairs enrolled in the Programming Research in Obesity, Growth, and Environmental Stressors (PROGRESS) birth cohort in Mexico City. Exposure to PM_2.5 was estimated at the residential level using a satellite based spatio-temporally resolved prediction model. Average relative LTL was measured in DNA isolated from blood collected at age 4-6 years using quantitative real-time polymerase chain reaction. Lin

SUBMITTER: Edzie J 

PROVIDER: S-EPMC11624059 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature