Omnigene-Gut^tm ensures fecal microbiome stability in the pediatric population.

ABSTRACT: Increasing evidence exists that the gut microbiome influences toxicity as well as outcomes in a variety of cancers. To investigate the role of the gut microbiome in pediatric neuro-oncology, microbiome analysis has been included in multiple prospective pediatric neuro-oncology clinical trials (NCT05009992, NCT04732065, NCT04775485). In these trials, the OMNIgene-GUT^tm preservation tubes are used for the collection of the feces. OMNIgene-GUT^tm has demonstrated reliability in preserving the composition of the gut microbiome in adults; however, its validation for use in the pediatric population remains limited. Therefore, we compared the quality of the DNA by 16S rRNA gene sequencing after various methods of stabilizing fecal samples in pediatric populations, from the di

SUBMITTER: Hoogendijk R 

PROVIDER: S-EPMC11624167 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature