The acyl-CoA-binding protein VdAcb1 is essential for carbon starvation response and contributes to virulence in <i>Verticillium dahliae</i>.

ABSTRACT: In the face of carbon, nitrogen, and phosphorus starvation, microorganisms have evolved adaptive mechanisms to maintain growth. In a previous study, we identified a protein predicted to contain acyl-CoA-binding domains in the plant pathogenic fungus Verticillium dahliae. The predicted protein, designated VdAcb1, possesses an atypical signal peptide. However, the functions of this acyl-CoA-binding protein in V. dahliae are not clear. In this research, in vivo or in vitro assays confirmed that VdAcb1 is secreted extracellularly from V. dahliae, although it does not have the typical signal peptide. Furthermore, the unconventional secretion of VdAcb1 was dependent on VdGRASP, a member of the compartment for unconventional protein secretion (CUPS). The deletion mutant strai

SUBMITTER: Zhuang J 

PROVIDER: S-EPMC11624172 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature