Single-cell transcriptome profiling of m⁶A regulator-mediated methylation modification patterns in elderly acute myeloid leukemia patients.

ABSTRACT: Millions of people worldwide die of acute myeloid leukaemia (AML) each year. Although N6-methyladenosine (m⁶A) modification has been reported to regulate the pathogenicity of AML, the mechanisms by which m⁶A induces dysfunctional hematopoietic differentiation in elderly AML patients remain elusive. This study elucidates the mechanisms of the m⁶A landscape and the specific roles of m⁶A regulators in hematopoietic cells of elderly AML patients. Notably, fat mass and obesity-associated protein (FTO) was found to be upregulated in hematopoietic stem cells (HSCs), myeloid cells, and T-cells, where it inhibits their differentiation via the WNT signaling pathway. Additionally, elevated YT521-B homology domain family proteins 2 (YTHDF2) expression in ery

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11624184 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature