Genetic linkage disequilibrium of deleterious mutations in threatened mammals.

ABSTRACT: The impact of negative selection against deleterious mutations in endangered species remains underexplored. Recent studies have measured mutation load by comparing the accumulation of deleterious mutations, however, this method is most effective when comparing within and between populations of phylogenetically closely related species. Here, we introduced new statistics, LDcor, and its standardized form nLDcor, which allows us to detect and compare global linkage disequilibrium of deleterious mutations across species using unphased genotypes. These statistics measure averaged pairwise standardized covariance and standardize mutation differences based on the standard deviation of alleles to reflect selection intensity. We then examined selection strength in the genomes of seven mammals. Tige

SUBMITTER: Hu C 

PROVIDER: S-EPMC11624202 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature