A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets.

ABSTRACT: Effective intracellular communication between cellular organelles occurs at dedicated membrane contact sites (MCSs). Tether proteins are responsible for the establishment of MCSs, enabling direct communication between organelles to ensure organelle function and host cell homeostasis. While recent research has identified tether proteins in several bacterial pathogens, their functions have predominantly been associated with mediating inter-organelle communication between the bacteria containing vacuole (BCV) and the host endoplasmic reticulum (ER). Here, we identify a novel bacterial effector protein, CbEPF1, which acts as a molecular tether beyond the confines of the BCV and facilitates interactions between host cell organelles. Coxiella burnetii, an obligate intracellular bacterial pathoge

SUBMITTER: Angara RK 

PROVIDER: S-EPMC11624262 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature