The Dectin-1 and Dectin-2 clusters: C-type lectin receptors with fundamental roles in immunity.

ABSTRACT: The ability of myeloid cells to recognize and differentiate endogenous or exogenous ligands rely on the presence of different transmembrane protein receptors. C-type lectin receptors (CLRs), defined by the presence of a conserved structural motif called C-type lectin-like domain (CTLD), are a crucial family of receptors involved in this process, being able to recognize a diverse range of ligands from glycans to proteins or lipids and capable of initiating an immune response. The Dectin-1 and Dectin-2 clusters involve two groups of CLRs, with genes genomically linked within the natural killer cluster of genes in both humans and mice, and all characterized by the presence of a single extracellular CTLD. Fundamental immune cell functions such as antimicrobial effector mechanisms as well as in

SUBMITTER: Malamud M 

PROVIDER: S-EPMC11624271 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature