Dexamethasone alleviates acute lung injury in a rat model with venovenous extracorporeal membrane oxygenation support.

ABSTRACT:

Background

In recent years, dexamethasone (Dex) has been used to treat acute respiratory distress syndrome (ARDS) in patients with COVID-19 and achieved promising outcomes. Venovenous extracorporeal membrane oxygenation (VV ECMO) support for patients with ARDS has increased significantly worldwide. However, it remains unknown whether Dex could improve the efficiency of VV ECMO to reduce lung injury. Here, we investigate the combined efficiency of VV ECMO and Dex in rats with acute lung injury (ALI).

Methods

We established VV ECMO in oleic acid (OA)-treated ALI rats and administered Dex. We conducted HE staining and evaluated lung and bronchoalveolar lavage (BAL) fluid cytokines to assess lung injury and inflammation. Furthermore, we investigated the activation of Hippo/YAP s

SUBMITTER: Wei SL 

PROVIDER: S-EPMC11624713 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature