Association of pre-existing conditions with major driver mutations and PD-L1 expression in NSCLC.

ABSTRACT:

Objectives

This study aims to explore how pre-existing conditions such as blood types, family history of cancer and comorbid diseases correlate with the genetic and programmed death-ligand 1 (PD-L1) expression that contributes to the heterogeneous biological behaviours of non-small cell lung cancer (NSCLC).

Materials and methods

A cohort of 5507 NSCLC patients who underwent surgical resection between January 2014 and July 2018 was studied. Targeted next-generation sequencing was used to detect mutations in nine pivotal cancer-related genes, and immunohistochemical staining was applied to assess PD-L1 expression. Logistic regression analysis was employed to identify significant correlations.

Results

All patients underwent NGS, with 1839 were also evaluated for PD-L1 ex

SUBMITTER: Chen P 

PROVIDER: S-EPMC11624786 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature