Differential predictive value of resident memory CD8⁺T cell subpopulations in patients with non-small-cell lung cancer treated by immunotherapy.

ABSTRACT:

Background

A high density of resident memory T cells (T_RM) in tumors correlates with improved clinical outcomes in immunotherapy-treated patients. In most clinical studies, T_RM are defined by the CD103 marker. However, it is clearly established that not all T_RM express CD103, but can be defined by other markers (CD49a, CD69, etc). The frequency of these subpopulations of T_RM expressing or not CD103 varies according to the location of the cancer. Little is known about their functionality and their predictive impact on response to immunotherapy. In preclinical models, only some subpopulations of T_RM are associated with cancer vaccine efficacy.

Methods

Multiparametric cytometry analyses were used to demonstrate the presence

SUBMITTER: Paolini L 

PROVIDER: S-EPMC11624836 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature