Identification and validation of apoptosis-related genes in acute myocardial infarction based on integrated bioinformatics methods.

ABSTRACT:

Background

Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Apoptosis is a type of programmed cell death that causes DNA degradation and chromatin condensation. The role of apoptosis in AMI progression remains unclear.

Methods

Three AMI-related microarray datasets (GSE48060, GSE66360 and GSE97320) were obtained from the Gene Expression Omnibus database and combined for further analysis. Differential expression analysis and enrichment analysis were performed on the combined dataset to identify differentially expressed genes (DEGs). Apoptosis-related genes (ARGs) were screened through the intersection of genes associated with apoptosis in previous studies and DEGs. The expression pattern of ARGs was studied on the basis of their raw express

SUBMITTER: Zhu H 

PROVIDER: S-EPMC11624842 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature