M2 macrophage derived HMOX1 defines chronic rhinosinusitis with nasal polyps.

ABSTRACT:

Background

Molecular signatures of chronic rhinosinusitis with nasal polyps (CRSwNP) related to macrophages remain unclear. This study aimed to develop a macrophage-associated diagnostic signature for CRSwNP.

Methods

Transcriptome data from 54 patients with CRSwNP and 37 healthy controls across GSE136825, GSE36830, and GSE72713 were used to identify differentially expressed genes (DEGs) between two groups. Gene Set Enrichment Analysis and Weighted Gene Co-Expression Network Analysis pinpointed crucial pathways and gene clusters. A diagnostic model was created from these analyses and receiver operating characteristic curve (ROC), and further validated in our transcriptome data from 29 samples. Immune cell infiltration analysis was performed and linked those diagnostic genes t

SUBMITTER: Wang E 

PROVIDER: S-EPMC11624889 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature