Per- and polyfluoroalkyl substances (PFAS) and hypertensive disorders of Pregnancy- integration of epidemiological and mechanistic evidence.

ABSTRACT:

Background

Hypertensive disorders of pregnancy (HDP) remain a significant global health burden despite medical advancements. HDP prevalence appears to be rising, leading to increased maternal and fetal complications, mortality, and substantial healthcare costs. The etiology of HDP are complex and multifaceted, influenced by factors like nutrition, obesity, stress, metabolic disorders, and genetics. Emerging evidence suggests environmental pollutants, particularly Per- and polyfluoroalkyl substances (PFAS), may contribute to HDP development.

Objective

This review integrates epidemiological and mechanistic data to explore the intricate relationship between PFAS exposure and HDP.

Epidemiological evidence

Studies show varying degrees of association between PFAS exposure a

SUBMITTER: Dangudubiyyam SV 

PROVIDER: S-EPMC11625001 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature