Mitigating the Nocebo Effect in Biosimilar Use and Switching: A Systematic Review.

ABSTRACT:

Background

In the context of biosimilar use and switching, a patient's negative perception of a biosimilar might trigger a nocebo effect, where negative expectations unrelated to its pharmacologic action may lead to worsened symptoms, resulting in less perceived therapeutic benefit or worsened adverse events. Considering the crucial role biosimilars have in reducing health care costs and expanding access to safe biologics globally, it is essential to develop and implement effective strategies to mitigate the possible occurrence of such nocebo effects.

Objective

The aim of this systematic literature review was two-fold: (i) to review strategies that have been applied and/or tested for minimising the nocebo effect in clinical practice, within and outside the context of biosimi

SUBMITTER: Car E 

PROVIDER: S-EPMC11625068 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature