Enhanced osteogenic potential of spider silk fibroin-based composite scaffolds incorporating carboxymethyl cellulose for bone tissue engineering.

ABSTRACT: This study aimed to investigate the characteristics of composite scaffolds that combine fibroin derived from spider silk and carboxymethyl cellulose (CMC) in the field of bone tissue engineering. Fibroin, obtained from spider silk, serves as a valuable biomaterial and constitutes the primary component of fibrous protein-based spider silk threads. To enhance the binding efficiency in bone formation after scaffold implantation, CMC was integrated into fibroin, aiming to improve the injectability properties of the scaffold in bone substitutes. For bone marrow mesenchymal stem cell (BMSC) tissue engineering, BMSCs isolated from mice were seeded onto the scaffold, and the rate of cell proliferation was assessed. The composite scaffold, with the addition of CMC to fibroin, exhibited superior cha

SUBMITTER: Lee WJ 

PROVIDER: S-EPMC11625154 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature