Characterization of the C5H11ORF96 gene in chickens: cloning, tissue distribution and investigation of its potential function in stress response regulation.

ABSTRACT: Chicken is an important economic animal that encounter various stressors including high temperature, high stocking density, bacterial infections and transportation, etc. affecting the poultry production with serious economic loss. To be in response to the varied stimulus, the hypothalamic-pituitary-adrenal (HPA) axis is activated through the controlling of the synthesis and secretion of glucocorticoids (GCs). Present study characterized a novel gene C5H11ORF96, that demonstrated significant upregulation after the DEX injection in chicken, which simulates the stress stimulus. Our results showed that: (1) cC5H11ORF96 cDNA encodes a 120 amino acids protein, which shares high sequence identity with that of birds, mammals, reptiles, frogs and fish; (2) cC5H11ORF96 has a fully conserved RFKTQP m

SUBMITTER: Wan Y 

PROVIDER: S-EPMC11625329 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature