Hepatocellular carcinoma risk scores for non-viral liver disease: A systematic review and meta-analysis.

ABSTRACT:

Background & aims

Hepatocellular carcinoma (HCC) risk prediction models may provide a more personalised approach to surveillance for HCC among patients with cirrhosis. This systematic review aims to summarise the performance of HCC prediction models in patients with non-viral chronic liver disease.

Method

The study was prospectively registered with PROSPERO (ID: CRD42022370078) and reported in accordance with PRISMA guidelines. MEDLINE and Embase databases were searched using a validated search filter for prediction model studies. Two reviewers independently assessed studies for inclusion and risk of bias. Measures of model performance (discrimination and calibration) to assess the risk of HCC at specified time points were identified. A random effects meta-analysis was perfo

SUBMITTER: Burke L 

PROVIDER: S-EPMC11625341 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature