Prostate cancer risk biomarkers from large cohort and prospective metabolomics studies: A systematic review.

ABSTRACT: Prostate cancer (PCa) is one of the leading causes of cancer-related deaths among men. The heterogeneous nature of this disease presents challenges in its diagnosis, prognosis, and treatment. Numerous potential predictive, diagnostic, prognostic, and risk assessment biomarkers have been proposed through various population studies. However, to date, no metabolite biomarker has been approved or validated for the diagnosis, prognosis, or risk assessment of PCa. Recognizing that systematic reviews of case reports or heterogenous studies cannot reliably establish causality, this review analyzed 29 large prospective metabolomics studies that utilized harmonized criteria for patient selection, consistent methodologies for blood sample collection and storage, data analysis, and that are available

SUBMITTER: Lopez-Hernandez Y 

PROVIDER: S-EPMC11625367 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature