Complement C3 knockout protects photoreceptors in the sodium iodate model.

ABSTRACT: Complement factor 3 (C3) has emerged as a primary therapeutic target in age-related macular degeneration (AMD) supported by genetic, histologic, and clinical trial evidence. Yet, the site(s) of action are unclear. The purpose of this study was to test the effect of C3 knockout on photoreceptors and retinal pigment epithelial cells (RPE) in the sodium iodate (NaIO₃) model, which mirrors some features of AMD. C3^-/- and WT mice, both on a C57Bl/6J background, were injected intraperitoneally with 25 mg/kg NaIO₃. Electroretinography and optical coherence tomography were performed 7 days later to assess retinal function and structure, respectively. Then, mice were euthanized for retinal immunohistochemistry, quantitative real-time PCR and enzyme-linked immunosorb

SUBMITTER: Wang T 

PROVIDER: S-EPMC11625604 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature