Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer's Disease.

ABSTRACT:

Background

While the amygdala receives early tau deposition in Alzheimer's disease (AD) and is involved in social and emotional processing, the relationship between amygdalar tau and early neuropsychiatric symptoms in AD is unknown. We sought to determine whether focal tau binding in the amygdala and abnormal amygdalar connectivity were detectable in a preclinical AD cohort and identify relationships between these and self-reported mood symptoms.

Methods

We examined 598 individuals (347 amyloid positive [58% female], 251 amyloid negative [62% female] subset in tau positron emission tomography and functional magnetic resonance imaging cohorts) from the A4 (Anti-Amyloid Treatment in Asymptomatic AD) Study. In the tau positron emission tomography cohort, we used amygdalar segme

SUBMITTER: Li JS 

PROVIDER: S-EPMC11625605 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature