Biomechanical evaluation of the porcine carpus as a potential preclinical animal model for the human carpus.

ABSTRACT: Advancing successful treatments for carpal instabilities of the wrist are hindered due, in part, to limited preclinical animal models. The purpose of this study was to evaluate the forelimb of the Yucatan minipig (YP) as a potential preclinical animal model for the human wrist by quantifying carpal biomechanics in vitro in the intact and after two ligament transection conditions. Porcine wrist biomechanics (n = 12, 5M, 7F) were determined in 28 range of motion (ROM) directions, in pronation-supination, and in volar-dorsal translation using a six-axis robotic musculoskeletal simulator. Testing was implemented in three conditions - intact, and after sequential transection of the radial intermediate ligament (RIL) and the dorsal intercarpal ligament (DIC). Mixed models were employed to examin

SUBMITTER: Altieri MK 

PROVIDER: S-EPMC11625608 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature