Dysfunctional Alpha Modulation as a Mechanism of Working Memory Impairment in Serious Mental Illness.

ABSTRACT:

Background

People with psychosis and mood disorders experience disruptions in working memory; however, the underlying mechanism remains unknown. We focused on 2 potential mechanisms: poor attentional engagement should be associated with elevated levels of prestimulus alpha-band activity within the electroencephalogram (EEG), whereas impaired working memory encoding should be associated with reduced poststimulus alpha suppression.

Methods

We collected EEG data from 68 people with schizophrenia, 43 people with bipolar disorder with a history of psychosis, 53 people with major depressive disorder, and 90 healthy comparison subjects while they completed a spatial working memory task. We quantified attention lapsing, memory precision, and memory capacity from the behavioral respo

SUBMITTER: Erickson MA 

PROVIDER: S-EPMC11625623 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature