Static and temporal dynamic changes of intrinsic brain activity in early-onset and adult-onset schizophrenia: a fMRI study of interaction effects.

ABSTRACT:

Background

Schizophrenia is characterized by altered static and dynamic spontaneous brain activity. However, the conclusions regarding this are inconsistent. Evidence has revealed that this inconsistency could be due to mixed effects of age of onset.

Methods

We enrolled 66/84 drug-naïve first-episode patients with early-onset/adult-onset schizophrenia (EOS/AOS) and matched normal controls (NCs) (46 adolescents, 73 adults), undergoing resting-state functional magnetic resonance imaging. Two-way ANOVA was used to determine the amplitude of low-frequency fluctuation (ALFF) and dynamic ALFF (dALFF) among the four groups.

Result

Compared to NCs, EOS had a higher ALFF in inferior frontal gyrus bilateral triangular part (IFG-tri), left opercular part (IFG-oper), left orbital

SUBMITTER: Chen J 

PROVIDER: S-EPMC11625647 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature