Single-Frequency Birdcage Coils for Deep Tissue Perfluorocarbon Magnetic Resonance Imaging in Mice.

ABSTRACT: Fluorine-19 (¹⁹F) MRI has become an established tool for in vivo cell tracking following ex vivo or in vivo labelling of various cell types with ¹⁹F perfluorocarbons (PFCs). Here, we developed and evaluated novel mouse-specific radiofrequency (RF) hardware for improved dual ¹H anatomical imaging and deep tissue ¹⁹F MR detection of PFCs. Three linearly polarized birdcage RF coils were constructed-a dual-frequency ¹H/¹⁹F coil, and a pair of single-frequency ¹H and ¹⁹F coils, designed to be used sequentially. RF coil quality factors (Q values), signal homogeneity and sensitivity were benchmarked against a commercially constructed dual-frequency ¹H/¹⁹F surface coil. RF homogeneity was

SUBMITTER: McRae SW 

PROVIDER: S-EPMC11625660 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature