A novel necroptosis-related genes signature to predict prognosis and treatment response in bladder cancer.

ABSTRACT:

Background

Necroptosis, a form of programmed inflammatory cell death, plays a crucial role in tumor development, necrosis, metastasis, and immune response. This study aimed to explore the role of necroptosis in BLCA and construct a new prognostic model to guide clinical treatment and predict individualized treatment response.

Methods

The transcriptome profiling and the corresponding clinical data of BLCA patients were obtained from the Cancer Genome Atlas database (TCGA) and GEO databases. Univariate, multivariate and LASSO Cox regression analyses were used to identify and construct prognostic features associated with necroptosis. We constructed and validated a prognostic model associated with the patient's overall survival (OS). A nomogram was established to predict the sur

SUBMITTER: Yao D 

PROVIDER: S-EPMC11625674 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature