Associations of motor and neuropsychiatric symptoms with comorbidities in prodromal Parkinson's disease.

ABSTRACT:

Objective

To investigate the associations between comorbidities and multimorbidity patterns with motor and neuropsychiatric symptoms in patients with Parkinson's disease (PD) in prodromal PD.

Methods

Multimorbidity is defined as the coexistence of two or more long-term conditions (LTCs) (also known as multiple comorbidities). A total of 921 participants without PD were included in the Parkinson's Progression Markers Initiative (PPMI) database and were categorized according to the LTC count. Participants were evaluated on motor and psychiatric symptoms. Pearson correlation to examine relationship of comorbidities and target symptoms. The baseline population was analyzed using Multiple linear regression model, while mixed effects model was utilized for longitudinal analysis. F

SUBMITTER: Chen JR 

PROVIDER: S-EPMC11625736 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature