Potential of gut microbiota metabolites in treating COPD: network pharmacology and Mendelian randomization approaches.

ABSTRACT:

Objective

The gut microbiota and its metabolites exert a significant influence on COPD, yet the underlying mechanisms remain elusive. We aim to holistically evaluate the role and mechanisms of the gut microbiota and its metabolites in COPD through network pharmacology and Mendelian randomization approaches.

Methods

Employing network pharmacology, we identified the gut microbiota and its metabolites' impact on COPD-related targets, elucidating the complex network mechanisms involving the gut microbiota, its metabolites, targets, and signaling pathways in relation to COPD. Further, promising gut microbiota metabolites and microbiota were pinpointed, with their causal relationships inferred through Mendelian randomization.

Results

A complex biological network was constru

SUBMITTER: Cao Z 

PROVIDER: S-EPMC11625750 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature