Evaluation of an attenuated chicken-origin <i>Histomonas meleagridis</i> vaccine for the prevention of histomonosis in chickens.

ABSTRACT:

Introduction

Histomonosis, a protozoan disease caused by Histomonas meleagridis, poses a significant economic burden on domestic poultry in China. To reduce the losses caused by this disease in chickens, an attenuated vaccine was developed by exploiting the diminished virulence of H. meleagridis through successive in vitro passages.

Methods

Four experiments were conducted to evaluate the viability of attenuated H. meleagridis as a potential vaccine candidate. Experiment 1 evaluated the route of infection (oral vs. intracloacal) and dose (5 × 10⁴, 1 × 10⁵, and 2 × 10⁵ H. meleagridis/chicken) using the virulent strain H. meleagridis JSYZ-D10. Experiment 2 evaluated the attenuated effect of the H. mel

SUBMITTER: Chen QG 

PROVIDER: S-EPMC11625761 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature