Ferroptosis exacerbates the clonal deletion of virus-specific exhausted CD8⁺ T cells.

ABSTRACT: During chronic infection or tumorigenesis, persistent antigen stimulation contributes to the exhaustion of CD8⁺ T cells. Nevertheless, exhausted CD8⁺ T (T_EX) cells still preserve certain effector function, and maintaining a reservoir of exhausted cells is of vital importance for virus elimination and tumor eradiation. Despite considerable work interrogating the rejuvenation of T_EX cells, mechanisms underpinning the clonal deletion of T_EX cells remain largely unexplored over the past decade. In this study, we employed mouse models of LCMV infection to demonstrate that excessive accumulation of lipid peroxidation rendered virus-specific T_EX cells to ferroptosis, which may correlate with enhanced mitochondria-derived oxidative

SUBMITTER: Tian Q 

PROVIDER: S-EPMC11625764 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature