Causal relationship between diabetes mellitus and lung cancer: a two-sample Mendelian randomization and mediation analysis.

ABSTRACT:

Background

Diabetes mellitus (DM) is the common comorbidity with lung cancer (LC), and metabolic disorders have been identified as significant contributors to the pathogenesis of both DM and LC. The causality between diabetes mellitus and lung cancer is still controversial. Hence, the causal effects of DM on the risk of LC was systemically investigated, and the mediating role of blood metabolites in this relationship was further explored.

Methods

This study utilized a comprehensive Mendelian randomization (MR) analysis to investigate the association between diabetes mellitus and lung cancer. The inverse variance weighted method was employed as the principle approach. MR Egger and weighted median were complementary calculations for MR assessment. A two-step MR analysis was pe

SUBMITTER: Yu X 

PROVIDER: S-EPMC11625780 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature