IAPP blocks anti-breast cancer function of CD8⁺T cells via targeting cuproptosis.

ABSTRACT:

Background

Breast cancer (BRCA) is the most prevalent type of cancer worldwide. As a highly heterogeneous cancer, it has a high recurrence rate. Since its biological behavior can be regulated by immunity and cuprotosis, so exploring potential therapeutic target to mediate immunity and cuprotosis is of great significance for BRCA therapy.

Methods

The immune-related genes and immune-cuprotosis-related deferentially expressed genes (ICR-DEGs) were identified by mining the TCGA database. Prognostic analysis, differential expression analysis, univariate and lasso regression analyses were used to determine their independent prognostic values. To evaluate the relationship between ICR-DEGs and immune scores, we constructed a prognostic risk model to evaluate immune checkpoints, and

SUBMITTER: Guo D 

PROVIDER: S-EPMC11625781 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature