Bidirectional two-sample Mendelian randomization study of atrial fibrillation and breast cancer.

ABSTRACT:

Background

Observational studies have shown an association between Breast Cancer (BC) and Atrial Fibrillation (AF). However, due to confounding factors and reverse causality, the causal role between BC and AF remains unclear. In this study, bidirectional two-sample Mendelian randomization (MR) combined with meta-analysis was used to evaluate the causal association between BC and AF.

Methods

Based on the Genome-Wide Association Studies (GWAS) summary data sets, the Inverse variance weighted (IVW) method was used as the main method, the weighted median method and MR-Egger method were used for Bidirectional Two-Sample Mendelian Randomization, and the Egger intercept test was used to detect horizontal pleiotropy. Heterogeneity was tested by Cochran's Q test, and sensitivity anal

SUBMITTER: Ding F 

PROVIDER: S-EPMC11625783 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature